Research Direction 1: “From 0 to 1” Targeted Anticancer Protein
Background: In clinical oncology, there are about 80 approved small-molecule targeted drugs. Most of them target oncoproteins whereas none targets tumor suppressor (the below figure). Mechanistically, a oncoprotein-targeting drug just need to inhibit protein function, with the molecular mechanisms of how a small molecule binds and inhibits protein is clear and understandable. However, a tumor […]