Research direction-2: drugging ‘smooth’ proteins without druggable pockets
Background: Among the 568 established therapeutical anticancer targets (Martinez-Jimenez, Nat Rev Can, 2020, 20, 555-572), a small number of them are overlappingly drugged (29/568; ~5%) whereas the vast majority of them remain “undruggable” (539/569; ~95%; the below figure). Mechanistically, the most of the drugged targets are kinases because they have a deep and narrow pocket for small […]