癌症与p53科普 – Page 2 – 卢敏课题组

The Min Lu Research Group

Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

State Key Laboratory of Omics and Disease (formerly State Key Laboratory of Medical Genomics)

The Min Lu Research Group

Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

State Key Laboratory of Omics and Disease (formerly State Key Laboratory of Medical Genomics)

癌症与p53科普

The tumor suppressor gene p53 undergoes mutations in half of cancer patients, with varying mutation frequencies across different types of cancer

2022年5月30日

癌症与p53科普

More than 1000 different p53 mutants have been detected in cancer so far

2022年5月30日

癌症与p53科普

The 25 most common p53 mutants

2022年5月30日

癌症与p53科普

Loss of anti-tumor function after p53 mutation is one of the main factors leading to cancer occurrence and death

2022年5月30日

癌症与p53科普

Although these over 1000 p53 mutations all cause p53 to lose its anti-tumor function, there are multiple pathways through which they cause p53 to lose its function. Therefore, different p53 mutants cannot be confused

2022年5月30日

癌症与p53科普

The research on p53 targeted drugs (i.e. drugs that can restore the anti-cancer function of p53 mutants) is highly challenging for two reasons

2022年5月30日

癌症与p53科普

Although at least 45 teams worldwide are researching drugs to treat p53 mutations, currently only arsenic agents can target p53 mutants and restore their anti-cancer function

2022年5月30日

癌症与p53科普

Even if arsenic agents have therapeutic effects, they are only effective against structural p53 mutants

2022年5月30日

癌症与p53科普

Population with p53 congenital mutations (LFS)

2022年5月30日

癌症与p53科普

Large scale double-blind randomized controlled clinical trials are the only basis for determining the effectiveness of anti-cancer drugs

2022年5月30日

The Min Lu Research Group

Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

State Key Laboratory of Omics and Disease (formerly State Key Laboratory of Medical Genomics)

The Min Lu Research Group©️Copyright