The research team carried out team-building activities in 2025 focusing on “alleviating scientific research pressure and stimulating innovative thinking”
In 2024, Song Huaxin obtained the project supported by NSFC for Young Scientists
The clinical research standards for P53 restorer proposed by the research group in 2025 were published in Nat Rev Cancer
Research Direction 1: “From 0 to 1” Targeted Anticancer Protein
Background: In clinical oncology, there are about 80 approved small-molecule targeted drugs. Most of them target oncoproteins whereas none targets tumor suppressor (the below figure). Mechanistically, a oncoprotein-targeting drug just need to inhibit protein function, with the molecular mechanisms of how a small molecule binds and inhibits protein is clear and understandable. However, a tumor […]
Research direction-2: drugging ‘smooth’ proteins without druggable pockets
Background: Among the 568 established therapeutical anticancer targets (Martinez-Jimenez, Nat Rev Can, 2020, 20, 555-572), a small number of them are overlappingly drugged (29/568; ~5%) whereas the vast majority of them remain “undruggable” (539/569; ~95%; the below figure). Mechanistically, the most of the drugged targets are kinases because they have a deep and narrow pocket for small […]
Members of the research team had a party and dinner at Meilan Lake, Shanghai
Researcher Lu Min served as the executive chair of the Youth Forum at the 18th National Congress of Experimental Hematology and delivered a keynote speech on “Targeting the Tumor Suppressor Protein p53.”
Experimental Hematology (CSEH), chairing the conference and giving an oral talk
Min Lu was invited and gave an oral talk on the 17th p53 international workshop
The research results of the research group have been highly praised by many senior experts from the fields of structure, clinical medicine, and small molecule of traditional Chinese medicine in the journal “Chemistry of Life”. It is considered a rare and domestically independent intellectual property innovation at the grassroots level
The members of the research group and Yan Ni celebrated their birthdays together
